Human DKK3 protein (Recombinant) (N-His) (STJP006133)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DKK3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DKK3 |
| Gene ID | 27122 |
| Uniprot ID | DKK3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala37-Ile350 |
Additional Info
| Post Translational Modifications | N- and O-glycosylated. |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| Protein Name | Dickkopf-Related Protein 3Dickkopf-3Dkk-3Hdkk-3 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Dickkopf-Related Protein 3 proteinDickkopf-3 proteinDkk-3 proteinHdkk-3 proteinDKK3 proteinREIC proteinUNQ258 proteinPRO295 protein |
Information sourced from Uniprot.org