Human Dkk-3 protein (Recombinant) (C-His&Avi) {Biotin} (STJP020227)
SPECIFICATIONS
HostHEK293 cells
ConjugationBiotin
ImmunogenBiotinylated Recombinant Human Dkk-3 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Pro23-Ile350) of Human Dkk-3 fused with a His and Avi tag at the C-terminal.
General Information
| Short Description | Recombinant-Human Dkk-3-C-His&Avi protein was developed in hek293 cells using the region Pro23-Ile350. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | DKK3 |
| Gene ID | 27122 |
| Uniprot ID | DKK3_HUMAN |
| Immunogen | Biotinylated Recombinant Human Dkk-3 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Pro23-Ile350) of Human Dkk-3 fused with a His and Avi tag at the C-terminal. |
| Immunogen Region | Pro23-Ile350 |
Additional Info
| Tissue Specificity | Highest expression in heart, brain, and spinal cord. |
| Post Translational Modifications | N- and O-glycosylated. |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| Protein Name | Dickkopf-Related Protein 3Dickkopf-3Dkk-3Hdkk-3 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Dickkopf-Related Protein 3 proteinDickkopf-3 proteinDkk-3 proteinHdkk-3 proteinDKK3 proteinREIC proteinUNQ258 proteinPRO295 protein |
Information sourced from Uniprot.org