Human DIO2 protein (Recombinant) (N-His) (STJP007664)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DIO2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DIO2 |
| Gene ID | 1734 |
| Uniprot ID | IOD2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu69-Leu269 |
Additional Info
| Post Translational Modifications | Ubiquitinated by MARCHF6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33. |
| Function | Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'- diiodothyronamine. |
| Protein Name | Type Ii Iodothyronine Deiodinase5diiDioiiType 2 DiType-Ii 5'-Deiodinase |
| Database Links | Reactome: R-HSA-350864Reactome: R-HSA-9844594 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iii Membrane Protein |
| Alternative Protein Names | Type Ii Iodothyronine Deiodinase protein5dii proteinDioii proteinType 2 Di proteinType-Ii 5'-Deiodinase proteinDIO2 proteinITDI2 proteinTXDI2 protein |
Information sourced from Uniprot.org