Function | Putative transcription factor, weakly pro-apoptotic when overexpressed. Tumor suppressor. Required for early embryonic stem cell development. Isoform 2: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. |
Protein Name | Death-Inducer Obliterator 1Dio-1Hdido1Death-Associated Transcription Factor 1Datf-1 |
Database Links | Reactome: R-HSA-1221632 Q9BTC0-1 |
Cellular Localisation | CytoplasmNucleusCytoskeletonSpindleTranslocates To The Nucleus After Pro-Apoptotic StimuliTranslocates To The Mitotic Spindle Upon Loss Of Interaction With H3k4me3 During Early Mitosis |
Alternative Protein Names | Death-Inducer Obliterator 1 proteinDio-1 proteinHdido1 proteinDeath-Associated Transcription Factor 1 proteinDatf-1 proteinDIDO1 proteinC20orf158 proteinDATF1 proteinKIAA0333 protein |
Information sourced from Uniprot.org