Human Dickkopf-1 (DKK1) protein (Recombinant) {Biotin} (STJP000190)


Current Stock:
Host: HEK293
Applications: ELISA, WB
Short Description: Recombinant-Human Dickkopf-1 (DKK1)-protein was developed from hek293. For use in research applications.
Conjugation: Biotin
Formulation: Recombinant Human Dickkopf-1 is lyophilized from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Storage Instruction: Recombinant DKK1 can be stored in working aliquots at 2-8°C for one month, or at-20°C to-70°C for twelve months. Avoid repeated freeze/thaw cycles.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: DKK1
Gene ID: 22943
Uniprot ID: DKK1_HUMAN
Immunogen Region: THR32-HIS266
Tissue Specificity Placenta.
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity.
Protein Name Dickkopf-Related Protein 1
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-3772470
Reactome: R-HSA-5339717
Cellular Localisation Secreted
Alternative Antibody Names Anti-Dickkopf-Related Protein 1 antibody
Anti-Dickkopf-1 antibody
Anti-Dkk-1 antibody
Anti-Hdkk-1 antibody
Anti-Sk antibody
Anti-DKK1 antibody
Anti-UNQ492 antibody
Anti-PRO1008 antibody

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12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance