||FOR RESEARCH USE ONLY (RUO).
||Recombinant-Human Dickkopf-1 (DKK1)-protein was developed from hek293. For use in research applications.
||Recombinant Human Dickkopf-1 is lyophilized from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
||Recombinant DKK1 can be stored in working aliquots at 2-8°C for one month, or at-20°C to-70°C for twelve months. Avoid repeated freeze/thaw cycles.
||Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
| Tissue Specificity || Placenta. |
| Function || Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. |
| Protein Name || Dickkopf-Related Protein 1Dickkopf-1Dkk-1Hdkk-1Sk |
| Database Links || Reactome: R-HSA-201681Reactome: R-HSA-3772470Reactome: R-HSA-5339717 |
| Cellular Localisation || Secreted |
| Alternative Antibody Names || Anti-Dickkopf-Related Protein 1 antibodyAnti-Dickkopf-1 antibodyAnti-Dkk-1 antibodyAnti-Hdkk-1 antibodyAnti-Sk antibodyAnti-DKK1 antibodyAnti-UNQ492 antibodyAnti-PRO1008 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance