Human DHX16 protein (Recombinant) (N-His) (STJP010692)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DHX16-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DHX16 |
| Gene ID | 8449 |
| Uniprot ID | DHX16_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu364-Glu746 |
Additional Info
| Function | Required for pre-mRNA splicing as a component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA. Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses. |
| Protein Name | Pre-Mrna-Splicing Factor Atp-Dependent Rna Helicase Dhx16Atp-Dependent Rna Helicase #3Deah-Box Protein 16 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleoplasmCytoplasm |
| Alternative Protein Names | Pre-Mrna-Splicing Factor Atp-Dependent Rna Helicase Dhx16 proteinAtp-Dependent Rna Helicase #3 proteinDeah-Box Protein 16 proteinDHX16 proteinDBP2 proteinDDX16 proteinKIAA0577 proteinPRP2 protein |
Information sourced from Uniprot.org