Human DHX15 protein (Recombinant) (N-His) (STJP007986)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DHX15-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DHX15 |
| Gene ID | 1665 |
| Uniprot ID | DHX15_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp568-Tyr795 |
Additional Info
| Function | RNA helicase involved in mRNA processing and antiviral innate immunity. Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome. Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3). Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses. The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu. Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells. |
| Protein Name | Atp-Dependent Rna Helicase Dhx15Atp-Dependent Rna Helicase #46Deah Box Protein 15Splicing Factor Prp43Hprp43 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Protein Names | Atp-Dependent Rna Helicase Dhx15 proteinAtp-Dependent Rna Helicase #46 proteinDeah Box Protein 15 proteinSplicing Factor Prp43 proteinHprp43 proteinDHX15 proteinDBP1 proteinDDX15 protein |
Information sourced from Uniprot.org