Human DGKZ protein (Recombinant) (N-His) (STJP005347)

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STJP005347
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DGKZ-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DGKZ
Gene ID: 8525
Uniprot ID: DGKZ_HUMAN
Immunogen Region: Val506-Ala743
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta.
Function Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group. The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol. By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization. Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane. Isoform 1: Regulates RASGRP1 activity. Isoform 2: Does not regulate RASGRP1 activity.
Protein Name Diacylglycerol Kinase Zeta
Dag Kinase Zeta
Diglyceride Kinase Zeta
Dgk-Zeta
Database Links Reactome: R-HSA-114508
Cellular Localisation Nucleus
Cytoplasm
Cytosol
Cell Membrane
Cell Projection
Lamellipodium
Alternative Protein Names Diacylglycerol Kinase Zeta protein
Dag Kinase Zeta protein
Diglyceride Kinase Zeta protein
Dgk-Zeta protein
DGKZ protein
DAGK6 protein

Information sourced from Uniprot.org