Human DGKH protein (Recombinant) (N-His) (STJP005658)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DGKH-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DGKH |
| Gene ID | 160851 |
| Uniprot ID | DGKH_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Cys329-Tyr462 |
Additional Info
| Post Translational Modifications | Phosphorylated. Phosphorylation does not inhibit catalytic activity. |
| Function | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization. |
| Protein Name | Diacylglycerol Kinase EtaDag Kinase EtaDiglyceride Kinase EtaDgk-Eta |
| Database Links | Reactome: R-HSA-114508 |
| Cellular Localisation | CytoplasmCell MembraneTranslocated From The Cytoplasm To Endosomes In Response To Stress StimuliIsoform 2 Is Rapidly Relocated Back To The Cytoplasm Upon Removal Of Stress StimuliWhereas Isoform 1 Exhibits Sustained Endosomal AssociationTranslocates From The Cytoplasm To The Cell Membrane In The Presence Of Active Gtp-Bound Form Of Hras |
| Alternative Protein Names | Diacylglycerol Kinase Eta proteinDag Kinase Eta proteinDiglyceride Kinase Eta proteinDgk-Eta proteinDGKH protein |
Information sourced from Uniprot.org