Human DEFB4A protein (Recombinant) (Tag free) (STJP014261)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DEFB4A-Tag free protein was developed from e.coli and has a target region of Tag free. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | DEFB4A.DEFB4B |
| Gene ID | 100289462/1673 |
| Uniprot ID | DFB4A_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly24-Pro64 |
Additional Info
| Function | Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria, with highest activity against Gram-negative bacteria. Antimicrobial activity against P.aruginosa seems to be salt-sensitive and is reduced with high salt concentrations greater than 25 mM. Also exhibits antimicrobial activity against the yeast C.albicans. Permeabilizes C.albicans cell membranes via targeting plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), thereby leading to cell fragmentation and cell death. Acts as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells, such as immature dendritic cells and memory T cells. |
| Protein Name | Defensin Beta 4aBeta-Defensin 2Bd-2Hbd-2Defensin - Beta 2Skin-Antimicrobial Peptide 1Sap1 |
| Database Links | Reactome: R-HSA-1461957Reactome: R-HSA-1461973 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Defensin Beta 4a proteinBeta-Defensin 2 proteinBd-2 proteinHbd-2 proteinDefensin - Beta 2 proteinSkin-Antimicrobial Peptide 1 proteinSap1 proteinDEFB4A proteinDEFB102 proteinDEFB2 proteinDEFB4.DEFB4B protein |
Information sourced from Uniprot.org