Human DEFB126 protein (Recombinant) (N-GST) (STJP005956)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DEFB126-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DEFB126 |
| Gene ID | 81623 |
| Uniprot ID | DB126_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asn21-Gly111 |
Additional Info
| Post Translational Modifications | O-glycosylated.glycans contain alpha(2,3)-linked sialic acids. |
| Function | Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection.both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte. In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation. |
| Protein Name | Beta-Defensin 126Beta-Defensin 26Defb-26Defensin - Beta 126Epididymal Secretory Protein 13.2Esp13.2Hbd26 |
| Database Links | Reactome: R-HSA-1461957Reactome: R-HSA-1461973 |
| Cellular Localisation | SecretedSecreted By Epididymal Cells And Is Absorbed To The Surface Of Sperm During Transit Through The EpididymisMainly Located On The Sperm Acrosome |
| Alternative Protein Names | Beta-Defensin 126 proteinBeta-Defensin 26 proteinDefb-26 proteinDefensin - Beta 126 proteinEpididymal Secretory Protein 13.2 proteinEsp13.2 proteinHbd26 proteinDEFB126 proteinC20orf8 proteinDEFB26 protein |
Information sourced from Uniprot.org