| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 34pg/mL |
| Detection Limit: | 78.1-5000pg/mL |
| Short Description: | This DEFb126 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | DEFB126 |
| Gene ID: | 81623 |
| Uniprot ID: | DB126_HUMAN |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | High-level and epididymis-specific expression. Expression is down-regulated in infertile men. |
| Post Translational Modifications | O-glycosylated.glycans contain alpha(2,3)-linked sialic acids. |
| Function | Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection.both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte. In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation. |
| Protein Name | Beta-Defensin 126 Beta-Defensin 26 Defb-26 Defensin - Beta 126 Epididymal Secretory Protein 13.2 Esp13.2 Hbd26 |
| Database Links | Reactome: R-HSA-1461957 Reactome: R-HSA-1461973 |
| Cellular Localisation | Secreted Secreted By Epididymal Cells And Is Absorbed To The Surface Of Sperm During Transit Through The Epididymis Mainly Located On The Sperm Acrosome |
| Alternative ELISA Names | Beta-Defensin 126 ELISA kit Beta-Defensin 26 ELISA kit Defb-26 ELISA kit Defensin - Beta 126 ELISA kit Epididymal Secretory Protein 13.2 ELISA kit Esp13.2 ELISA kit Hbd26 ELISA kit DEFB126 ELISA kit C20orf8 ELISA kit DEFB26 ELISA kit |
| output |
Information sourced from Uniprot.org
