SDS-PAGE of recombinant human DEFB118 protein under reducing conditions with Coomassie blue stain

Human DEFB118 protein (Recombinant) (His-Tag) (STJP018553)

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STJP018553
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Short Description :Recombinant-Human DEFB118-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% Glycerol, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:DEFB118
Gene ID:117285
Uniprot ID:DB118_HUMAN
Accession Number:NP_473453
Immunogen:Human
Immunogen Region:21-123aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MGSYSGEKKC WNRSGHCRKQ CKDGEAVKDT CKNLRACCIP SNEDHRRVPA TSPTPLSDST PGIIDDILTV RFTTDYFEVS SKKDMVEESE AGRGTETSLP NVHHSS
Tissue Specificity High-level and epididymis-specific expression. Most abundant in the epithelium of the caput and present in the epididymis lumen and bound to sperm. Also expressed in pancreas.
Post Translational Modifications The three-dimensional structure formed by the three intramolecular disulfide bridges is indispensable for antimicrobial activity.
Function Host defense peptide that exhibits antimicrobial activity against both Gram-negative bacteria, such as E.coli and S.typhimurium, and Gram-positive bacteria, such as S.aureus and B.subtilis. Inhibits cell adhesion of E.coli on intestinal epithelial enterocytes. Causes rapid permeabilization of both the outer and inner membrane of E.coli, leading to morphological alterations on the bacterial surface. Binds to bacterial lipopolysaccharides (LPS) with high affinity, and may thereby be involved in immunoregulation through LPS neutralization. May contribute to epididymal innate immunity and protect the sperm against attack by microorganisms.
Protein Name Defensin Beta 118
Beta-Defensin 18
Defb-18
Epididymal Secretory Protein 13.6
Esp13.6
Database Links Reactome: R-HSA-1461957
Reactome: R-HSA-1461973
Cellular Localisation Secreted
Alternative Protein Names Defensin Beta 118 protein
Beta-Defensin 18 protein
Defb-18 protein
Epididymal Secretory Protein 13.6 protein
Esp13.6 protein
DEFB118 protein
C20orf63 protein
DEFB18 protein
ESC42 protein

Information sourced from Uniprot.org

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