Human DEDD protein (Recombinant) (N-His) (STJP010742)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DEDD-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DEDD |
| Gene ID | 9191 |
| Uniprot ID | DEDD_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln191-Pro318 |
Additional Info
| Post Translational Modifications | Exists predominantly in a mono- or diubiquitinated form. |
| Function | A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro. |
| Protein Name | Death Effector Domain-Containing ProteinDedpro1Death Effector Domain-Containing Testicular MoleculeFlded-1 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusNucleolusTranslocated To The Nucleus During Cd95-Mediated Apoptosis Where It Is Localized In The NucleoliFollowing Apoptosis InductionThe Mono And/Or Diubiquitination Form Increases And Forms Filamentous Structures That Colocalize With Krt8 And Krt18 Intermediate Filament Network In Simple Epithelial Cells |
| Alternative Protein Names | Death Effector Domain-Containing Protein proteinDedpro1 proteinDeath Effector Domain-Containing Testicular Molecule proteinFlded-1 proteinDEDD proteinDEDPRO1 proteinDEFT proteinKE05 protein |
Information sourced from Uniprot.org