Human DEDD protein (Recombinant) (His-Tag) (STJP018052)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human DEDD-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DEDD |
| Gene ID | 9191 |
| Uniprot ID | DEDD_HUMAN |
| Accession Number | NP_127491 |
| Immunogen | Human |
| Immunogen Region | 1-318aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Widely expressed with highest levels in testis. |
| Post Translational Modifications | Exists predominantly in a mono- or diubiquitinated form. |
| Function | A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro. |
| Protein Name | Death Effector Domain-Containing ProteinDedpro1Death Effector Domain-Containing Testicular MoleculeFlded-1 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusNucleolusTranslocated To The Nucleus During Cd95-Mediated Apoptosis Where It Is Localized In The NucleoliFollowing Apoptosis InductionThe Mono And/Or Diubiquitination Form Increases And Forms Filamentous Structures That Colocalize With Krt8 And Krt18 Intermediate Filament Network In Simple Epithelial Cells |
| Alternative Protein Names | Death Effector Domain-Containing Protein proteinDedpro1 proteinDeath Effector Domain-Containing Testicular Molecule proteinFlded-1 proteinDEDD proteinDEDPRO1 proteinDEFT proteinKE05 protein |
Information sourced from Uniprot.org