Human DDX5 protein (Recombinant) (C-Strep) (STJP015181)
SPECIFICATIONS
HostInsect Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DDX5-C-Strep protein was developed from insect cells for the region C-Strep. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Insect Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-230°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | DDX5 |
| Gene ID | 1655 |
| Uniprot ID | DDX5_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys40-Gly481 |
Additional Info
| Function | Involved in the alternative regulation of pre-mRNA splicing.its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation.the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner.the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. |
| Protein Name | Probable Atp-Dependent Rna Helicase Ddx5Dead Box Protein 5Rna Helicase P68 |
| Database Links | Reactome: R-HSA-3899300Reactome: R-HSA-72163Reactome: R-HSA-9018519Reactome: R-HSA-9682706Reactome: R-HSA-9694686 |
| Cellular Localisation | NucleusNucleolusNucleus SpeckleCytoplasmDuring The G0 PhasePredominantly Located In The NucleusCytoplasmic Levels Increase During The G1/S PhaseDuring The M PhaseLocated At The Vicinity Of The Condensed ChromosomesAt G1Localizes In The Cytoplasm |
| Alternative Protein Names | Probable Atp-Dependent Rna Helicase Ddx5 proteinDead Box Protein 5 proteinRna Helicase P68 proteinDDX5 proteinG17P1 proteinHELR proteinHLR1 protein |
Information sourced from Uniprot.org