Human DDHD2 protein (Recombinant) (N-His) (STJP008847)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DDHD2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DDHD2 |
| Gene ID | 23259 |
| Uniprot ID | DDHD2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln212-Asn363 |
Additional Info
| Function | Diacylglycerol (DAG) and triacylglycerol (TAG) lipase required for proper lipid homeostasis in the central nervous system. It cooperates with PNPLA2/ATGL in neuronal TAG catabolism and hydrolyzes sn-1,3 DAG downstream of PNPLA2/ATGL. In vitro, it also acts as a phospholipase that hydrolyzes preferentially phosphatidic acids, including 1,2-dioleoyl-sn-phosphatidic acid, phosphatidylcholine and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane. |
| Protein Name | Triacylglycerol Hydrolase Ddhd2Tag HydrolaseDdhd Domain-Containing Protein 2Kiaa0725pPhospholipase Ddhd2Sam - Wwe And Ddhd Domain-Containing Protein 1Triglyceride Hydrolase Ddhd2Triglyceride Lipase |
| Database Links | Reactome: R-HSA-1483166 |
| Cellular Localisation | CytoplasmCytosolEndoplasmic Reticulum-Golgi Intermediate CompartmentGolgi ApparatusCis-Golgi NetworkCycles Between The Golgi Apparatus And The CytosolDdhd2 Recruitment To The Golgi/Endoplasmic Reticulum-Golgi Intermediate Compartment (Ergic) Is Regulated By The Levels Of PhosphoinositidesIncluding Pi(4)P |
| Alternative Protein Names | Triacylglycerol Hydrolase Ddhd2 proteinTag Hydrolase proteinDdhd Domain-Containing Protein 2 proteinKiaa0725p proteinPhospholipase Ddhd2 proteinSam - Wwe And Ddhd Domain-Containing Protein 1 proteinTriglyceride Hydrolase Ddhd2 proteinTriglyceride Lipase proteinDDHD2 proteinKIAA0725 proteinSAMWD1 protein |
Information sourced from Uniprot.org