Human DCUN1D1 protein (Recombinant) (N-His) (STJP014800)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DCUN1D1-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | DCUN1D1 |
| Gene ID | 54165 |
| Uniprot ID | DCNL1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Val259 |
Additional Info
| Post Translational Modifications | Mono- and poly-ubiquitinated by ARIH2 and ARIH1. Monoubiquitination by ARIH2 is mediated by an interaction between autoubiquitinated ARIH2 and the UBA-like domain. The monoubiquitinated form preferentially interacts with non-neddylated cullins and modulates cullin RING ligase (CRL) complex composition and activity. |
| Function | Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Also acts as an oncogene facilitating malignant transformation and carcinogenic progression. |
| Protein Name | Dcn1-Like Protein 1Dcnl1Dcun1 Domain-Containing Protein 1Defective In Cullin Neddylation Protein 1-Like Protein 1Squamous Cell Carcinoma-Related Oncogene |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | NucleusCytoplasmThe Ubiquitinated Form Is Localized In The Cytoplasm |
| Alternative Protein Names | Dcn1-Like Protein 1 proteinDcnl1 proteinDcun1 Domain-Containing Protein 1 proteinDefective In Cullin Neddylation Protein 1-Like Protein 1 proteinSquamous Cell Carcinoma-Related Oncogene proteinDCUN1D1 proteinDCN1 proteinDCUN1L1 proteinRP42 proteinSCCRO protein |
Information sourced from Uniprot.org