| Short Description : | Recombinant-Human DCNL2/DCUN1D2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications: | SDS-PAGE |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Concentration: | 1 mg/mL |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% Glycerol, 0.1M NaCl |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DCUN1D2 |
| Gene ID: | 55208 |
| Uniprot ID: | DCNL2_HUMAN |
| Accession Number: | NP_001014305 |
| Immunogen: | Human |
| Immunogen Region: | 1-259aa |
| Immunogen Sequence: | MGSSHHHHHH SSGLVPRGSH MHKLKSSQKD KVRQFMACTQ AGERTAIYCL TQNEWRLDEA TDSFFQNPDS LHRESMRNAV DKKKLERLYG RYKDPQDENK IGVDGIQQFC DDLSLDPASI SVLVIAWKFR AATQCEFSRK EFLDGMTELG CDSMEKLKAL LPRLEQELKD TAKFKDFYQF TFTFAKNPGQ KGLDLEMAVA YWKLVLSGRF KFLDLWNTFL MEHHKRSI |
| Tissue Specificity | Mostly expressed in liver, kidney and brain. |
| Function | Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and plays an essential role in the regulation of SCF (SKP1-CUL1-F-box protein)-type complexes activity. |
| Protein Name | Dcn1-Like Protein 2Dcnl2Dcun1 Domain-Containing Protein 2Defective In Cullin Neddylation Protein 1-Like Protein 2 |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Dcn1-Like Protein 2 proteinDcnl2 proteinDcun1 Domain-Containing Protein 2 proteinDefective In Cullin Neddylation Protein 1-Like Protein 2 proteinDCUN1D2 proteinC13orf17 proteinDCUN1L2 protein |
Information sourced from Uniprot.org
