Human DCD protein (Recombinant) (N-His) (STJP005096)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DCD-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DCD |
| Gene ID | 117159 |
| Uniprot ID | DCD_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Cys18-Leu110 |
Additional Info
| Function | DCD-1: Found in sweat, has an antimicrobial activity during early bacterial colonization. The secreted peptide assembles into homohexameric complexes that can associate with and also insert into pathogen membranes. Once inserted in bacteria membranes forms anion channels probably altering the transmembrane potential essential for bacterial survival. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues. Survival-promoting peptide: Promotes survival of neurons and displays phosphatase activity. It may bind IgG. |
| Protein Name | DermcidinPreproteolysin Cleaved Into - Survival-Promoting Peptide - Dcd-1 |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedSurvival-Promoting Peptide: SecretedDcd-1: SecretedMembranePeripheral Membrane ProteinSingle-Pass Membrane ProteinThe Secreted Peptide Assembles Into Homohexameric Complexes That Can Probably Associate With Pathogen Membranes And Also Insert Into These Membranes Where They Behave As Channels |
| Alternative Protein Names | Dermcidin proteinPreproteolysin Cleaved Into - Survival-Promoting Peptide - Dcd-1 proteinDCD proteinAIDD proteinDSEP protein |
Information sourced from Uniprot.org