Human DBNL protein (Recombinant) (N-His) (STJP015199)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DBNL-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | DBNL |
| Gene ID | 28988 |
| Uniprot ID | DBNL_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Gly137 |
Additional Info
| Function | Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. |
| Protein Name | Drebrin-Like ProteinCervical Sh3p7Cervical Mucin-Associated ProteinDrebrin-FHpk1-Interacting Protein Of 55 KdaHip-55Sh3 Domain-Containing Protein 7 |
| Database Links | Reactome: R-HSA-264870Reactome: R-HSA-6794361Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionLamellipodiumRuffleCell CortexCytosolSynapsePerikaryonNeuron ProjectionCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic VesicleClathrin-Coated Vesicle MembraneGolgi Apparatus MembranePodosomeEarly EndosomeDendritePostsynaptic DensityAssociates With Lamellipodial Actin And Membrane RufflesColocalizes With Actin And Cortactin At Podosome Dots And Podosome Rosettes |
| Alternative Protein Names | Drebrin-Like Protein proteinCervical Sh3p7 proteinCervical Mucin-Associated Protein proteinDrebrin-F proteinHpk1-Interacting Protein Of 55 Kda proteinHip-55 proteinSh3 Domain-Containing Protein 7 proteinDBNL proteinCMAP proteinSH3P7 proteinPP5423 protein |
Information sourced from Uniprot.org