Human Cytoglobin/CYGB protein (Recombinant) (His-Tag) (STJP016732)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Cytoglobin/CYGB-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CYGB |
| Gene ID | 114757 |
| Uniprot ID | CYGB_HUMAN |
| Accession Number | AAH29798 |
| Immunogen | Human |
| Immunogen Region | 1-190aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Widely expressed. Highest expression in heart, stomach, bladder and small intestine. |
| Post Translational Modifications | The formation of an intramolecular disulfide bond between cysteines Cys-38 and Cys-83 specifically enhances the nitrite reductase activity. |
| Function | Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability. Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption. By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and vascular tone. Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide. Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress. Also binds dioxygen with low affinity and could function as an oxygen sensor but has probably no function as a respiratory oxygen carrier. |
| Protein Name | CytoglobinHistoglobinHgbNitric Oxygen Dioxygenase CygbNodNitrite Reductase CygbPseudoperoxidase CygbStellate Cell Activation-Associated ProteinSuperoxide Dismutase Cygb |
| Database Links | Reactome: R-HSA-203615Reactome: R-HSA-8981607 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Cytoglobin proteinHistoglobin proteinHgb proteinNitric Oxygen Dioxygenase Cygb proteinNod proteinNitrite Reductase Cygb proteinPseudoperoxidase Cygb proteinStellate Cell Activation-Associated Protein proteinSuperoxide Dismutase Cygb proteinCYGB proteinSTAP protein |
Information sourced from Uniprot.org