Human CYTH2 protein (Recombinant) (His-Tag) (STJP017860)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CYTH2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CYTH2 |
| Gene ID | 9266 |
| Uniprot ID | CYH2_HUMAN |
| Accession Number | NP_004219 |
| Immunogen | Human |
| Immunogen Region | 1-399aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMEDGVYE PPDLTPEERM ELENIRRRKQ ELLVEIQRLR EELSEAMSEV EGLEANEGSK TLQRNRKMAM GRKKFNMDPK KGIQFLVENE LLQNTPEEIA RFLYKGEGLN KTAIGDYLGE REELNLAVLH AFVDLHEFTD LNLVQALRQF LWSFRLPGEA QKIDRMMEAF AQRYCLCNPG VFQSTDTCYV LSFAVIMLNT SLHNPNVR |
Additional Info
| Tissue Specificity | Widely expressed. |
| Function | Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. Involved in neurite growth. |
| Protein Name | Cytohesin-2Arf Exchange FactorArf Nucleotide-Binding Site OpenerProtein ArnoPh - Sec7 And Coiled-Coil Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-6811438 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmCell ProjectionGrowth ConeCell JunctionTight JunctionAdherens JunctionBoth Isoform 1 And Isoform 2 Are Recruited To The Cell Membrane Through Its Association With Arl4aArl4c And Arl4dThey Require Also Interaction With Phosphoinositides For Targeting To Plasma MembraneIn Differentiating Neuroblastoma CellsColocalizes With Ccdc120 In Both Neurite Shaft And Growth Cone Areas |
| Alternative Protein Names | Cytohesin-2 proteinArf Exchange Factor proteinArf Nucleotide-Binding Site Opener proteinProtein Arno proteinPh - Sec7 And Coiled-Coil Domain-Containing Protein 2 proteinCYTH2 proteinARNO proteinPSCD2 proteinPSCD2L protein |
Information sourced from Uniprot.org