| Short Description : | Recombinant-Human Cystatin-SN/CST1-C-His protein was developed in hek293 cells using the region Trp21-Ser141. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured by its ability to inhibit active Cathepsin L cleavage of a fluorogenic peptide substrate Z-LR-AMC. The IC50 value is <11.0 nM. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | CST1 |
| Gene ID: | 1469 |
| Uniprot ID: | CYTN_HUMAN |
| Immunogen: | Recombinant Human Cystatin-SN/CST1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Trp21-Ser141) of human Cystatin SN/CST1 (Accession #NP_001889.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Region: | Trp21-Ser141 |
| Immunogen Sequence: | WSPKEEDRIIPGGIYNADLN DEWVQRALHFAISEYNKATK DDYYRRPLRVLRARQQTVGG VNYFFDVEVGRTICTKSQPN LDTCAFHEQPELQKKQLCSF EIYEVPWENRRSLVKSRCQE S |
| Function | Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well. |
| Protein Name | Cystatin-SnCystain-Sa-ICystatin-1Salivary Cystatin-Sa-1 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Cystatin-Sn proteinCystain-Sa-I proteinCystatin-1 proteinSalivary Cystatin-Sa-1 proteinCST1 protein |
Information sourced from Uniprot.org
