| Short Description : | Recombinant-Human Cystatin-D/CST5-C-His protein was developed in hek293 cells using the region Gly21-Val142. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured by its ability to inhibit papain cleavage of a fluorogenic peptide substrate Z-FR-AM. The IC50 value is <18 nM. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | CST5 |
| Gene ID: | 1473 |
| Uniprot ID: | CYTD_HUMAN |
| Immunogen: | Recombinant Human Cystatin-D/CST5 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly21-Val142) of human Cystatin D (Accession #NP_001891.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Region: | Gly21-Val142 |
| Immunogen Sequence: | GSASAQSRTLAGGIHATDLN DKSVQCALDFAISEYNKVIN KDEYYSRPLQVMAAYQQIVG GVNYYFNVKFGRTTCTKSQP NLDNCPFNDQPKLKEEEFCS FQINEVPWEDKISILNYKCR KV |
| Function | Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B. |
| Protein Name | Cystatin-DCystatin-5 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Cystatin-D proteinCystatin-5 proteinCST5 protein |
Information sourced from Uniprot.org
