| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of 20mM Tris, 150mM NaCl, pH 8.0. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1.0 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its ability to inhibit papain cleavage of a fluorogenic peptide substrate Z-FR-AMC. The IC50 value is <0.7 nM. |
| Gene Symbol: | CSTA |
| Gene ID: | 1475 |
| Uniprot ID: | CYTA_HUMAN |
| Immunogen Region: | Met1-Phe98 |
| Immunogen: | Recombinant Human Cystatin-A/CSTA Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Phe98) of human Cystatin-A (Accession #NP_005204.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | AAIGSCSKEYRVLLGQLQKQ TDLMQDTSRLLDPYIRIQGL DVPKLREHCRERPGAFPSEE TLRGLGRRGFLQTLNATLGC VLHRLADLEQRLPKAQDLER SGLNIEDLEKLQMARPNILG LRNNIYCMAQLLDNSDTAEP TKAGRGASQPPTPTPASDAF QRKLEGCRFLHGYHRFMHSV GRVFSKWGESPNRSRR |
| Tissue Specificity | Expressed in the skin throughout the epidermis. |
| Function | This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis. |
| Protein Name | Cystatin-ACystatin-AsStefin-A Cleaved Into - Cystatin-A - N-Terminally Processed |
| Database Links | Reactome: R-HSA-6809371 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Cystatin-A proteinCystatin-As proteinStefin-A Cleaved Into - Cystatin-A - N-Terminally Processed proteinCSTA proteinSTF1 proteinSTFA protein |
Information sourced from Uniprot.org