| Function | A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19. Catalyzes the hydroxylation of 11-deoxycortisol and 11-deoxycorticosterone (21-hydroxyprogesterone) at 11beta position, yielding cortisol or corticosterone, respectively, but cannot produce aldosterone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Due to its lack of 18-oxidation activity, it is incapable of generating aldosterone. Could also be involved in the androgen metabolic pathway (Probable). |
| Protein Name | Cytochrome P450 11b1 - MitochondrialCyp11b1Cypxib1Cytochrome P-450c11Cytochrome P450c11Steroid 11-Beta-Hydroxylase - Cyp11b1 |
| Database Links | Reactome: R-HSA-194002Reactome: R-HSA-211976Reactome: R-HSA-5579017 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane Protein |
| Alternative Protein Names | Cytochrome P450 11b1 - Mitochondrial proteinCyp11b1 proteinCypxib1 proteinCytochrome P-450c11 proteinCytochrome P450c11 proteinSteroid 11-Beta-Hydroxylase - Cyp11b1 proteinCYP11B1 proteinS11BH protein |
Information sourced from Uniprot.org
