Human CYGB protein (Recombinant) (C-His) (STJP014675)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CYGB-C-His protein was developed from e.coli and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 10% Glycerol, pH 8.0. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | CYGB |
| Gene ID | 114757 |
| Uniprot ID | CYGB_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Pro190 |
Additional Info
| Post Translational Modifications | The formation of an intramolecular disulfide bond between cysteines Cys-38 and Cys-83 specifically enhances the nitrite reductase activity. |
| Function | Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability. Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption. By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and vascular tone. Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide. Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress. Also binds dioxygen with low affinity and could function as an oxygen sensor but has probably no function as a respiratory oxygen carrier. |
| Protein Name | CytoglobinHistoglobinHgbNitric Oxygen Dioxygenase CygbNodNitrite Reductase CygbPseudoperoxidase CygbStellate Cell Activation-Associated ProteinSuperoxide Dismutase Cygb |
| Database Links | Reactome: R-HSA-203615Reactome: R-HSA-8981607 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Cytoglobin proteinHistoglobin proteinHgb proteinNitric Oxygen Dioxygenase Cygb proteinNod proteinNitrite Reductase Cygb proteinPseudoperoxidase Cygb proteinStellate Cell Activation-Associated Protein proteinSuperoxide Dismutase Cygb proteinCYGB proteinSTAP protein |
Information sourced from Uniprot.org