Human Cyclin A2 protein (Recombinant) (His-Tag) (STJP017685)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Cyclin A2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol 0.15M NaCl, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CCNA2 |
| Gene ID | 890 |
| Uniprot ID | CCNA2_HUMAN |
| Accession Number | NP_001228.1 |
| Immunogen | Human |
| Immunogen Region | 1-432aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase. Ubiquitinated during the G1 phase by the SCF(FBXO31) complex, leading to its proteasomal degradation. |
| Function | Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. |
| Protein Name | Cyclin-A2Cyclin-ACyclin A |
| Database Links | Reactome: R-HSA-1362300Reactome: R-HSA-1538133Reactome: R-HSA-170145Reactome: R-HSA-171319Reactome: R-HSA-174184Reactome: R-HSA-176408Reactome: R-HSA-187577Reactome: R-HSA-2559582Reactome: R-HSA-2559586Reactome: R-HSA-5689880Reactome: R-HSA-5693607Reactome: R-HSA-6804116Reactome: R-HSA-6804756Reactome: R-HSA-6804757Reactome: R-HSA-68911Reactome: R-HSA-68949Reactome: R-HSA-69017Reactome: R-HSA-69273Reactome: R-HSA-69563Reactome: R-HSA-69656 |
| Cellular Localisation | NucleusCytoplasmExclusively Nuclear During InterphaseDetected In The Nucleus And The Cytoplasm At ProphaseCytoplasmic When Associated With Scaper |
| Alternative Protein Names | Cyclin-A2 proteinCyclin-A proteinCyclin A proteinCCNA2 proteinCCN1 proteinCCNA protein |
Information sourced from Uniprot.org