Human CUEDC2 protein (Recombinant) (His-Tag) (STJP018402)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CUEDC2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CUEDC2 |
| Gene ID | 79004 |
| Uniprot ID | CUED2_HUMAN |
| Accession Number | NP_076945 |
| Immunogen | Human |
| Immunogen Region | 1-287aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors. |
| Function | Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. |
| Protein Name | Cue Domain-Containing Protein 2 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Cue Domain-Containing Protein 2 proteinCUEDC2 proteinC10orf66 proteinHOYS6 protein |
Information sourced from Uniprot.org