Human CUBN protein (Recombinant) (N-His) (STJP003315)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CUBN-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CUBN |
| Gene ID | 8029 |
| Uniprot ID | CUBN_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Cys3511-Ser3623 |
Additional Info
| Post Translational Modifications | The precursor is cleaved by a trans-Golgi proteinase furin, removing a propeptide. N-glycosylated. |
| Function | Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. |
| Protein Name | Cubilin460 Kda ReceptorIntestinal Intrinsic Factor ReceptorIntrinsic Factor-Cobalamin ReceptorIntrinsic Factor-Vitamin B12 Receptor |
| Database Links | Reactome: R-HSA-196791Reactome: R-HSA-3359462Reactome: R-HSA-3359463Reactome: R-HSA-8964011Reactome: R-HSA-9758881 |
| Cellular Localisation | Apical Cell MembranePeripheral Membrane ProteinCell MembraneMembraneCoated PitEndosomeLysosome MembraneLacks A Transmembrane Domain And Depends On Interaction With Amn For Location At The Plasma MembraneColocalizes With Amn And Lrp2 In The Endocytotic Apparatus Of Epithelial Cells |
| Alternative Protein Names | Cubilin protein460 Kda Receptor proteinIntestinal Intrinsic Factor Receptor proteinIntrinsic Factor-Cobalamin Receptor proteinIntrinsic Factor-Vitamin B12 Receptor proteinCUBN proteinIFCR protein |
Information sourced from Uniprot.org