Human CTNND1 protein (Recombinant) (N-His) (STJP007873)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CTNND1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CTNND1 |
| Gene ID | 1500 |
| Uniprot ID | CTND1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu367-Gln601 |
Additional Info
| Post Translational Modifications | Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ. |
| Function | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. |
| Protein Name | Catenin Delta-1Cadherin-Associated Src SubstrateCasP120 CateninP120(CtnP120(Cas |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-5218920Reactome: R-HSA-8876493Reactome: R-HSA-9762292Reactome: R-HSA-9764302Reactome: R-HSA-9833576 |
| Cellular Localisation | Cell JunctionAdherens JunctionCytoplasmNucleusCell MembraneInteraction With Glis2 Promotes Nuclear TranslocationDetected At Cell-Cell ContactsNanos1 Induces Its Translocation From Sites Of Cell-Cell Contact To The CytoplasmCdh1 Enhances Cell Membrane LocalizationLocalizes To Cell-Cell Contacts As Keratinocyte Differentiation ProgressesIsoform 1a: NucleusIsoform 2a: NucleusIsoform 3a: NucleusIsoform 4a: CytoplasmIsoform 1ab: Cytoplasm |
| Alternative Protein Names | Catenin Delta-1 proteinCadherin-Associated Src Substrate proteinCas proteinP120 Catenin proteinP120(Ctn proteinP120(Cas proteinCTNND1 proteinKIAA0384 protein |
Information sourced from Uniprot.org