Human CTDSPL protein (Recombinant) (His-Tag) (STJP017531)

Name: Human CTDSPL protein (Recombinant) (His-Tag) (STJP017531)
SKU: STJP017531
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP017531

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Short Description	Recombinant-Human CTDSPL-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.5 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 40% Glycerol, 0.15M NaCl, 1mM DTT
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	CTDSPL
Gene ID	10217
Uniprot ID	CTDSL_HUMAN
Accession Number	NP_005799
Immunogen	Human
Immunogen Region	82-265aa
Immunogen Sequence	MGSSHHHHHH SSGLVPRGSH MGSHMKYLLP EVTVLDYGKK CVVIDLDETL VHSSFKPISN ADFIVPVEID GTIHQVYVLK RPHVDEFLQR MGQLFECVLF TASLAKYADP VADLLDRWGV FRARLFRESC VFHRGNYVKD LSRLGRELSK VIIVDNSPAS YIFHPENAVP VQSWFDDMTD TELLDLIPFF EGLSREDDVY SMLHRLCNR

Tissue Specificity	Expression is restricted to non-neuronal tissues.
Function	Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.
Protein Name	Ctd Small Phosphatase-Like Protein Ctdsp-Like Carboxy-Terminal Domain Rna Polymerase Ii Polypeptide A Small Phosphatase 3 Nif-Like Protein Nuclear Lim Interactor-Interacting Factor 1 Nli-Interacting Factor 1 Protein Ya22 Hya22 Rbsp3 Small C-Terminal Domain Phosphatase 3 Scp3 Small Ctd Phosphatase 3
Database Links
Cellular Localisation	Nucleus
Alternative Protein Names	Ctd Small Phosphatase-Like Protein protein Ctdsp-Like protein Carboxy-Terminal Domain Rna Polymerase Ii Polypeptide A Small Phosphatase 3 protein Nif-Like Protein protein Nuclear Lim Interactor-Interacting Factor 1 protein Nli-Interacting Factor 1 protein Protein Ya22 protein Hya22 protein Rbsp3 protein Small C-Terminal Domain Phosphatase 3 protein Scp3 protein Small Ctd Phosphatase 3 protein CTDSPL protein C3orf8 protein NIF1 protein NIFL protein SCP3 protein YA22 protein

Information sourced from Uniprot.org