Human CTBP1 protein (Recombinant) (No-Tag) (STJP016636)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CTBP1-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 100mM NaCl, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CTBP1 |
| Gene ID | 1487 |
| Uniprot ID | CTBP1_HUMAN |
| Accession Number | NP_001319.1 |
| Immunogen | Human |
| Immunogen Region | 1-440aa |
| Immunogen Sequence | MGSSHLLNKG LPLGVRPPIM NGPLHPRPLV ALLDGRDCTV EMPILKDVAT VAFCDAQSTQ EIHEKVLNEA VGALMYHTIT LTREDLEKFK ALRIIVRIGS GFDNIDIKSA GDLGIAVCNV PAASVEETAD STLCHILNLY RRATWLHQAL REGTRVQSVE QIREVASGAA RIRGETLGII GLGRVGQAVA LRAKAFGFNV LFYDPYLSDG VERALGLQRV STLQDLLF |
Additional Info
| Tissue Specificity | Expressed in germinal center B-cells. |
| Post Translational Modifications | The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation. ADP-ribosylated.when cells are exposed to brefeldin A. Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4. |
| Function | Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. |
| Protein Name | C-Terminal-Binding Protein 1Ctbp1 |
| Database Links | Reactome: R-HSA-3769402Reactome: R-HSA-3899300Reactome: R-HSA-4641265Reactome: R-HSA-5339700 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | C-Terminal-Binding Protein 1 proteinCtbp1 proteinCTBP1 proteinCTBP protein |
Information sourced from Uniprot.org