Human CSNK1G2 protein (Recombinant) (N-His) (STJP014580)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CSNK1G2-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 500mM NaCl, 10% Glycerol, 1mM DTT, pH 8.0. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | CSNK1G2 |
| Gene ID | 1455 |
| Uniprot ID | KC1G2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Lys415 |
Additional Info
| Post Translational Modifications | Autophosphorylated. Phosphorylated by aPKC which promotes dissociation from the cell cortex. |
| Function | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. Involved in regulation of reactive oxygen species (ROS) levels. |
| Protein Name | Casein Kinase I Isoform Gamma-2Cki-Gamma 2 |
| Database Links | Reactome: R-HSA-1660661Reactome: R-HSA-4641262 |
| Cellular Localisation | CytoplasmCell Cortex |
| Alternative Protein Names | Casein Kinase I Isoform Gamma-2 proteinCki-Gamma 2 proteinCSNK1G2 proteinCK1G2 protein |
Information sourced from Uniprot.org