Human Crystallin alpha B/CRYAB protein (Recombinant) (His-Tag) (STJP019549)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Crystallin alpha B/CRYAB-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CRYAB |
| Gene ID | 1410 |
| Uniprot ID | CRYAB_HUMAN |
| Accession Number | NP_001876.1 |
| Immunogen | Human |
| Immunogen Region | 1-175aa |
| Immunogen Sequence | MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFPT STSLSPFYLR PPSFLRAPSW FDTGLSEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV HGKHEERQDE HGFISREFHR KYRIPADVDP LTITSSLSSD GVLTVNGPRK QVSGPERTIP ITREEKPAVT AAPKK |
Additional Info
| Tissue Specificity | Lens as well as other tissues. Expressed in myocardial tissue. |
| Function | May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome. |
| Protein Name | Alpha-Crystallin B ChainAlpha(B-CrystallinHeat Shock Protein Beta-5Hspb5Heat Shock Protein Family B Member 5Renal Carcinoma Antigen Ny-Ren-27Rosenthal Fiber Component |
| Database Links | Reactome: R-HSA-3371571 |
| Cellular Localisation | CytoplasmNucleusSecretedLysosomeTranslocates To The Nucleus During Heat Shock And Resides In Sub-Nuclear Structures Known As Sc35 Speckles Or Nuclear Splicing SpecklesLocalizes At The Z-Bands And The Intercalated Disk In CardiomyocytesCan Be SecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Protein Names | Alpha-Crystallin B Chain proteinAlpha(B-Crystallin proteinHeat Shock Protein Beta-5 proteinHspb5 proteinHeat Shock Protein Family B Member 5 proteinRenal Carcinoma Antigen Ny-Ren-27 proteinRosenthal Fiber Component proteinCRYAB proteinCRYA2 proteinHSPB5 protein |
Information sourced from Uniprot.org