Human CRTAM/CD355 (A65V) protein (Recombinant) (C-His) (STJP002331)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human CRTAM Protein is expressed from HEK293 cells with a His tag at the C-terminal.；It contains Ser18-Gly287.
General Information
| Short Description | Recombinant-Human CRTAM/CD355 (A65V)-C-His protein was developed in hek293 cells using the region Ser18-Gly287. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.01 EU/Mu g by the LAL method. |
Target Information
| Gene Symbol | CRTAM |
| Gene ID | 56253 |
| Uniprot ID | CRTAM_HUMAN |
| Immunogen | Recombinant Human CRTAM Protein is expressed from HEK293 cells with a His tag at the C-terminal.；It contains Ser18-Gly287. |
| Immunogen Region | Ser18-Gly287 |
| Immunogen Sequence | LTNHTETITVEEGQTLTLKC VTSLRKNSSLQWLTPSGFTI FLNEYPVLKNSKYQLLHHSA NQLSITVPNVTLQDEGVYKC LHYSDSVSTKEVKVIVLATP FKPILEASVIRKQNGEEHVV LMCSTMRSKPPPQITWLLGN SMEVSGGTLHEFETDGKKCN TTSTLIIHTYGKNSTVDCII RHRGLQGRKLVAPFRFEDLV TDEETASDALERNSLSSQDP QQPTSTVSVTEDSSTSEID |
Additional Info
| Function | Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets. Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation. Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity. Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production. By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node. Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells. Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells. |
| Protein Name | Cytotoxic And Regulatory T-Cell MoleculeClass-I Mhc-Restricted T-Cell-Associated MoleculeCd Antigen Cd355 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIn A Subset Of Cd4+ T-CellsColocalizes With Scrib At The Immunological Synapse During The Late Phase Of T-Cell Activation |
| Alternative Protein Names | Cytotoxic And Regulatory T-Cell Molecule proteinClass-I Mhc-Restricted T-Cell-Associated Molecule proteinCd Antigen Cd355 proteinCRTAM protein |
Information sourced from Uniprot.org