Human CRHR1 protein (Recombinant) (N-His-SUMO) (STJP008226)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CRHR1-N-His-SUMO protein was developed from e.coli for the region N-His-SUMO. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CRHR1 |
| Gene ID | 1394 |
| Uniprot ID | CRFR1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser24-Lys113 |
Additional Info
| Post Translational Modifications | C-terminal Ser or Thr residues may be phosphorylated. Phosphorylation at Ser-301 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling. |
| Function | G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. |
| Protein Name | Corticotropin-Releasing Factor Receptor 1Crf-R-1Crf-R1Crfr-1Corticotropin-Releasing Hormone Receptor 1Crh-R-1Crh-R1 |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndosomeAgonist-Binding Promotes Endocytosis |
| Alternative Protein Names | Corticotropin-Releasing Factor Receptor 1 proteinCrf-R-1 proteinCrf-R1 proteinCrfr-1 proteinCorticotropin-Releasing Hormone Receptor 1 proteinCrh-R-1 proteinCrh-R1 proteinCRHR1 proteinCRFR proteinCRFR1 proteinCRHR protein |
Information sourced from Uniprot.org