Human CREB3L3 protein (Recombinant) (N-His) (STJP005568)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CREB3L3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CREB3L3 |
| Gene ID | 84699 |
| Uniprot ID | CR3L3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Thr322 |
Additional Info
| Post Translational Modifications | Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). N- and O-glycosylated. N-glycosylation is required for optimal proteolytic activation. O-glycosylated with core 1 or possibly core 8 glycans. Ubiquitinated at Lys-294 by SYNV1/HRD1 via 'Lys-27'-linked ubiquitin. |
| Function | Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE. May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription. Plays a crucial role in the regulation of triglyceride metabolism and is required for the maintenance of normal plasma triglyceride concentrations. |
| Protein Name | Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 3Camp-Responsive Element-Binding Protein 3-Like Protein 3Transcription Factor Creb-H Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 3 |
| Database Links | Reactome: R-HSA-8874211Reactome: R-HSA-8963889 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinProcessed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 3: NucleusUnder Er Stress The Cleaved N-Terminal Cytoplasmic Domain Translocates Into The Nucleus |
| Alternative Protein Names | Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 3 proteinCamp-Responsive Element-Binding Protein 3-Like Protein 3 proteinTranscription Factor Creb-H Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 3 proteinCREB3L3 proteinCREBH proteinHYST1481 protein |
Information sourced from Uniprot.org