Human CRADD protein (Recombinant) (Tag free) (STJP014583)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CRADD-Tag free protein was developed from e.coli and has a target region of Tag free. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in 20mM PB, 150mM NaCl, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | CRADD |
| Gene ID | 8738 |
| Uniprot ID | CRADD_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Glu199 |
Additional Info
| Function | Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway. |
| Protein Name | Death Domain-Containing Protein CraddCaspase And Rip Adapter With Death DomainRip-Associated Protein With A Death Domain |
| Database Links | Reactome: R-HSA-6803207 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Death Domain-Containing Protein Cradd proteinCaspase And Rip Adapter With Death Domain proteinRip-Associated Protein With A Death Domain proteinCRADD proteinRAIDD protein |
Information sourced from Uniprot.org