Human CR2/CD21 protein (Recombinant) (C-Avi&6His) (STJP020102)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human CR2/CD21 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile21-Arg971) of Human CR2/CD21 (Accession #NP_001868.2) fused with Avi and His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human CR2/CD21-C-Avi&6His protein was developed in hek293 cells using the region Ile21-Arg971. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CR2 |
| Gene ID | 1380 |
| Uniprot ID | CR2_HUMAN |
| Immunogen | Recombinant Human CR2/CD21 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile21-Arg971) of Human CR2/CD21 (Accession #NP_001868.2) fused with Avi and His tag at the C-terminus. |
| Immunogen Region | Ile21-Arg971 |
| Immunogen Sequence | ISCGSPPPILNGRISYYSTP IAVGTVIRYSCSGTFRLIGE KSLLCITKDKVDGTWDKPAP KCEYFNKYSSCPEPIVPGGY KIRGSTPYRHGDSVTFACKT NFSMNGNKSVWCQANNMWGP TRLPTCVSVFPLECPALPMI HNGHHTSENVGSIAPGLSVT YSCESGYLLVGEKIINCLSS GKWSAVPPTCEEARCKSLGR FPNGKVKEPPILRVGVTANF FCDEGYRLQGPPSSRCVIA |
Additional Info
| Tissue Specificity | Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen. |
| Function | Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner. Acts as a ligand for CD23 (FcepsilonRII), a low-affinity receptor for IgE, which is expressed on B-cells and other immune cells, and thus participates in the regulation of IgE production. (Microbial infection) Acts as a receptor for Epstein-Barr virus. |
| Protein Name | Complement Receptor Type 2Cr2Complement C3d ReceptorEpstein-Barr Virus ReceptorEbv ReceptorCd Antigen Cd21 |
| Database Links | Reactome: R-HSA-977606 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Complement Receptor Type 2 proteinCr2 proteinComplement C3d Receptor proteinEpstein-Barr Virus Receptor proteinEbv Receptor proteinCd Antigen Cd21 proteinCR2 proteinC3DR protein |
Information sourced from Uniprot.org