Human CPT1A (Carnitine Palmitoyltransferase 1A, Liver) Sandwich ELISA Kit (STJE0008116)
SPECIFICATIONS
General Information
| Short Description | This CPT1A Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.29ng/mL |
| Detection Limit | 0.781-50ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | CPT1A |
| Gene ID | 1374 |
| Uniprot ID | CPT1A_HUMAN |
| Sample Type | tissue homogenates, cell lysates or other biological fluids. |
Additional Info
| Tissue Specificity | Strong expression in kidney and heart, and lower in liver and skeletal muscle. |
| Post Translational Modifications | |
| Function | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity. Plays an important role in hepatic triglyceride metabolism. Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression. Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation. Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways. |
| Protein Name | Carnitine O-Palmitoyltransferase 1 - Liver IsoformCpt1-LCarnitine O-Palmitoyltransferase I - Liver IsoformCpt ICpti-LCarnitine Palmitoyltransferase 1aSuccinyltransferase Cpt1a |
| Database Links | Reactome: R-HSA-1368082Reactome: R-HSA-1989781Reactome: R-HSA-200425 |
| Cellular Localisation | Mitochondrion Outer MembraneMulti-Pass Membrane Protein |
| Alternative ELISA Names | Carnitine O-Palmitoyltransferase 1 - Liver Isoform ELISA kitCpt1-L ELISA kitCarnitine O-Palmitoyltransferase I - Liver Isoform ELISA kitCpt I ELISA kitCpti-L ELISA kitCarnitine Palmitoyltransferase 1a ELISA kitSuccinyltransferase Cpt1a ELISA kitCPT1A ELISA kitCPT1 ELISA kit |
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Information sourced from Uniprot.org