Human CPEB4/CPE-BP4 protein (Recombinant) (N-His) (STJP015164)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CPEB4/CPE-BP4-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-213°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | CPEB4 |
| Gene ID | 80315 |
| Uniprot ID | CPEB4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu468-Ala705 |
Additional Info
| Function | Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited. Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation. Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT. Stimulates proliferation of melanocytes. In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory. |
| Protein Name | Cytoplasmic Polyadenylation Element-Binding Protein 4Cpe-Bp4Cpe-Binding Protein 4Hcpeb-4 |
| Database Links | |
| Cellular Localisation | CytoplasmCell ProjectionDendriteDendritic SpinePostsynaptic DensityAxonGrowth ConeEndoplasmic ReticulumPerinuclear Region |
| Alternative Protein Names | Cytoplasmic Polyadenylation Element-Binding Protein 4 proteinCpe-Bp4 proteinCpe-Binding Protein 4 proteinHcpeb-4 proteinCPEB4 proteinKIAA1673 protein |
Information sourced from Uniprot.org