Human COQ6 protein (Recombinant) (N-His) (STJP006253)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human COQ6-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | COQ6 |
| Gene ID | 51004 |
| Uniprot ID | COQ6_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Lys468 |
Additional Info
| Function | FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-decaprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid. Also acts downstream of COQ4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-decaprenyl)phenol to 2-methoxy-6-(all-trans-decaprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to COQ6 from NADPH via a ferredoxin/ferredoxin reductase system composed of FDX2 and FDXR. |
| Protein Name | Ubiquinone Biosynthesis Monooxygenase Coq6 - Mitochondrial2-Methoxy-6-Polyprenolphenol 4-HydroxylaseCoenzyme Q10 Monooxygenase 6 |
| Database Links | Reactome: R-HSA-2142789 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix SideGolgi ApparatusCell ProjectionLocalizes To Cell Processes And Golgi Apparatus In Podocytes |
| Alternative Protein Names | Ubiquinone Biosynthesis Monooxygenase Coq6 - Mitochondrial protein2-Methoxy-6-Polyprenolphenol 4-Hydroxylase proteinCoenzyme Q10 Monooxygenase 6 proteinCOQ6 proteinCGI-10 protein |
Information sourced from Uniprot.org