Name: Human COPS7A protein (Recombinant) (His-Tag) (STJP018748)
SKU: STJP018748
Availability: InStock

Human COPS7A protein (Recombinant) (His-Tag) (STJP018748)

SKU:

STJP018748

£134.50 - £738.50

Short Description :	Recombinant-Human COPS7A-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:	SDS-PAGE/Denatured
Host:	E.coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration:	0.5 mg/mL
Formulation:	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol
Storage Instruction:	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol:	COPS7A
Gene ID:	50813
Uniprot ID:	CSN7A_HUMAN
Accession Number:	NP_001157566
Immunogen:	Human
Immunogen Region:	1-275aa
Immunogen Sequence:	MGSSHHHHHH SSGLVPRGSH MGSMSAEVKV TGQNQEQFLL LAKSAKGAAL ATLIHQVLEA PGVYVFGELL DMPNVRELAE SDFASTFRLL TVFAYGTYAD YLAEARNLPP LTEAQKNKLR HLSVVTLAAK VKCIPYAVLL EALALRNVRQ LEDLVIEAVY ADVLRGSLDQ RNQRLEVDYS IGRDIQRQDL SAIARTLQEW CVGCEVVLSG IEEQVSRANQ HKEQQLGL

Tissue Specificity	Widely expressed. Expressed at high level in brain, heart and skeletal muscle.
Post Translational Modifications	Phosphorylated by CK2 and PKD kinases.
Function	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Protein Name	Cop9 Signalosome Complex Subunit 7a Sgn7a Signalosome Subunit 7a Dermal Papilla-Derived Protein 10 Jab1-Containing Signalosome Subunit 7a
Database Links	Reactome: R-HSA-5696394 Reactome: R-HSA-6781823 Reactome: R-HSA-8856825 Reactome: R-HSA-8951664
Cellular Localisation	Cytoplasm Nucleus
Alternative Protein Names	Cop9 Signalosome Complex Subunit 7a protein Sgn7a protein Signalosome Subunit 7a protein Dermal Papilla-Derived Protein 10 protein Jab1-Containing Signalosome Subunit 7a protein COPS7A protein CSN7A protein DERP10 protein

Information sourced from Uniprot.org

Human COPS7A protein (Recombinant) (His-Tag) (STJP018748)

General Information

Model	Name	Host	Application
STJP019170	Human FGB protein (Recombinant) (His-Tag) (STJP019170)	E.coli	SDS-PAGE
STJP019149	Human PYCR2 protein (Recombinant) (His-Tag) (STJP019149)	E.coli	SDS-PAGE
STJP019163	Human ALDH6A1 protein (Recombinant) (His-Tag) (STJP019163)	E.coli	SDS-PAGE
STJP019189	Human UBE2Q2 protein (Recombinant) (His-Tag) (STJP019189)	E.coli	SDS-PAGE
STJP019134	Human ETNK2 protein (Recombinant) (His-Tag) (STJP019134)	E.coli	SDS-PAGE