Human COPS6 protein (Recombinant) (His-Tag) (STJP018365)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human COPS6-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | COPS6 |
| Gene ID | 10980 |
| Uniprot ID | CSN6_HUMAN |
| Accession Number | NP_006824 |
| Immunogen | Human |
| Immunogen Region | 1-327aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MAAAAAAAAA TNGTGGSSGM EVDAAVVPSV MACGVTGSVS VALHPLVILN ISDHWIRMRS QEGRPVQVIG ALIGKQEGRN IEVMNSFELL SHTVEEKIII DKEYYYTKEE QFKQVFKELE FLGWYTTGGP PDPSDIHVHK QVCEIIESPL FLKLNPMTKH TDLPVSVFES VIDIINGEAT MLFAELTYTL ATEEAERIGV DHVARMTA |
Additional Info
| Tissue Specificity | Widely expressed. |
| Function | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets. |
| Protein Name | Cop9 Signalosome Complex Subunit 6Sgn6Signalosome Subunit 6Jab1-Containing Signalosome Subunit 6Mov34 HomologVpr-Interacting ProteinHvip |
| Database Links | Reactome: R-HSA-5696394Reactome: R-HSA-6781823Reactome: R-HSA-8856825Reactome: R-HSA-8951664 |
| Cellular Localisation | NucleusCytoplasmPerinuclear Region(Microbial Infection) The Interaction With Hiv-1 Vpr Protein Possibly Leads Its Translocation To A Perinuclear Region |
| Alternative Protein Names | Cop9 Signalosome Complex Subunit 6 proteinSgn6 proteinSignalosome Subunit 6 proteinJab1-Containing Signalosome Subunit 6 proteinMov34 Homolog proteinVpr-Interacting Protein proteinHvip proteinCOPS6 proteinCSN6 proteinHVIP protein |
Information sourced from Uniprot.org