Human Complement Factor B protein (Recombinant) (His-Tag) (STJP018579)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Complement Factor B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CFB |
| Gene ID | 629 |
| Uniprot ID | CFAB_HUMAN |
| Accession Number | NP_001701 |
| Immunogen | Human |
| Immunogen Region | 260-764aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Cleaved by CFD following activation of the alternative complement system, generating Ba and Bb chains. Cleavage and activation takes place when CFB is already associated with complement C3b. |
| Function | Precursor of the catalytic component of the C3 and C5 convertase complexes of the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The alternative complement pathway acts as an amplification loop that enhances other complement pathways (classical, lectin and GZMK) by promoting formation of additional C3 and C5 convertases. CFB is cleaved and activated by CFD to generate Ba and Bb chains.Bb chain constituting the catalytic component of the C3 and C5 convertases. Complement factor B Bb: Serine protease component of the complement C3 and C5 convertase complexes of the alternative complement pathway. Following cleavage and activation by factor D (CFD), forms the C3 convertase together with complement C3b. As part of the C3 convertase, cleaves and activates C3 into C3a anaphylatoxin and C3b opsonin, the next components of the complement pathways. When an additional complement C3b molecule binds to the C3 convertase, forms the C5 convertase, which cleaves and activates C5 into C5a anaphylatoxin and C5b component of the membrane attack complex. Complement factor B Ba: Involved in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. |
| Protein Name | Complement Factor BC3/C5 ConvertaseGlycine-Rich Beta GlycoproteinGbgPbf2Properdin Factor B Cleaved Into - Complement Factor B BaBa - Complement Factor B BbBb |
| Database Links | Reactome: R-HSA-173736Reactome: R-HSA-174577Reactome: R-HSA-977606 |
| Cellular Localisation | SecretedComplement Factor B Bb: Cell SurfaceRecruited To The Surface Of Pathogens By Complement C3b Opsonin |
| Alternative Protein Names | Complement Factor B proteinC3/C5 Convertase proteinGlycine-Rich Beta GlycoproteinGbg proteinPbf2 proteinProperdin Factor B Cleaved Into - Complement Factor B Ba proteinBa - Complement Factor B Bb proteinBb proteinCFB proteinBF proteinBFD protein |
Information sourced from Uniprot.org