Human COMP (Cartilage Oligomeric Matrix Protein) Antibody Pair (STJAP00241)
General Information
| Short Description | This COMP antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Mouse/Rabbit |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Polyclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A.Detection Purification: Protein A & Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | COMP |
| Gene ID | 1311 |
| Uniprot ID | COMP_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human COMP protein.Detection Immunogen: Recombinant Human COMP protein. |
Additional Info
| Post Translational Modifications | Proteolytically cleaved by metalloproteases ADAMTS4 and ADAMTS1 with ADAMTS4 showing more potent activity. |
| Function | Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7. |
| Protein Name | Cartilage Oligomeric Matrix ProteinCompThrombospondin-5Tsp5 |
| Database Links | Reactome: R-HSA-216083Reactome: R-HSA-3000178 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Pair Names | Cartilage Oligomeric Matrix Protein antibody pairComp antibody pairThrombospondin-5 antibody pairTsp5 antibody pairCOMP antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human COMP (Cartilage Oligomeric Matrix Protein) Antibody Pair (STJAP00241)
This antibody pair is designed to detect human Cartilage Oligomeric Matrix Protein (COMP), corresponding to UniProt entry P49747. Reactivity is confirmed for human samples only.
The capture antibody is an unconjugated mouse monoclonal antibody, while the detection antibody is a biotin-conjugated rabbit polyclonal antibody. Both are supplied at 0.5 mg/mL in PBS with 0.04% Proclin 300 and 50% glycerol at pH 7.4.
This pair is validated for use in ELISA. It is intended for research use only and is not validated for diagnostic or therapeutic applications.
The capture antibody was purified by Protein A, while the detection antibody was purified by both Protein A and antigen affinity methods. Both were raised against recombinant human COMP protein as the immunogen.
Both components should be stored at -20°C for long-term storage. Freeze-thaw cycles should be avoided to maintain antibody integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.