| Short Description : | Recombinant-Human COMMD7-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications: | SDS-PAGE |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Concentration: | 1 mg/mL |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | COMMD7 |
| Gene ID: | 149951 |
| Uniprot ID: | COMD7_HUMAN |
| Accession Number: | NP_444269 |
| Immunogen: | Human |
| Immunogen Region: | 1-200aa |
| Immunogen Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMGRLHCT EDPVPEAVGG DMQQLNQLGA QQFSALTEVL FHFLTEPKEV ERFLAQLSEF ATTNQISLGS LRSIVKSLLL VPNGALKKSL TAKQVQADFI TLGLSEEKAT YFSEKWKQNA PTLARWAIGQ TLMINQLIDM EWKFGVTSGS SELEKVGSIF LQLKLVVKKG NQTENVYIEL TLPQFYSFLH EMERVRTSME CFC |
| Tissue Specificity | Widely expressed with highest expression in lung. |
| Function | Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos.the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Associates with the NF-kappa-B complex and suppresses its transcriptional activity. |
| Protein Name | Comm Domain-Containing Protein 7 |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | Cytoplasmic Vesicle |
| Alternative Protein Names | Comm Domain-Containing Protein 7 proteinCOMMD7 proteinC20orf92 protein |
Information sourced from Uniprot.org
