Human COLEC12 protein (Recombinant) (N-His) (STJP016129)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human COLEC12-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | COLEC12 |
| Gene ID | 81035 |
| Uniprot ID | COL12_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu603-Leu742 |
Additional Info
| Function | Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Also binds to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease. |
| Protein Name | Collectin-12Collectin Placenta Protein 1Cl-P1Hcl-P1Nurse Cell Scavenger Receptor 2Scavenger Receptor Class A Member 4Scavenger Receptor With C-Type Lectin |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-3000480 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane ProteinForms Clusters On The Cell Surface |
| Alternative Protein Names | Collectin-12 proteinCollectin Placenta Protein 1 proteinCl-P1 proteinHcl-P1 proteinNurse Cell Scavenger Receptor 2 proteinScavenger Receptor Class A Member 4 proteinScavenger Receptor With C-Type Lectin proteinCOLEC12 proteinCLP1 proteinNSR2 proteinSCARA4 proteinSRCL protein |
Information sourced from Uniprot.org